PPIRE15229

Target Protein Information
Protein_Name Immunoglobulin heavy constant epsilon
Protein_Sequence VSVKAPSLYPLKPCSSENTASVTLGCLVKDYFPDPVTVTWYSDSLNTSTMNFPSIGSDLKTTTSQMTSWGKSAKNFTCHVTHAPSTFVSDLTIRARPVNITKPTVDLLHSSCDPNAFHSTIQLYCFVYGHIQNDVSIHWLMDDRKIYETHAQNVLIKEEGKLASTYSRLNITQQQWMSESTFTCKVTSQGENYWAHTRRCSDDEPRGVITYLIPPSPLDLYENGTPKLTCLVLDLESEENITVTWVRERKKSIGSASQRSTKHHNATTSITSILPVDAKDWIEGEGYQCRVDHPHFPKPIVRSITKAPGKRSAPEVYVFLPPEEEEKDKRTLTCLIQNFFPEDISVQWLQDSKLIPKSQHSTTTPLKYNGSNQRFFIFSRLEVTKALWTQTKQFTCRVIHEALREPRKLERTISKSLGNTSLRPSQASM
Organism_Source Rattus norvegicus
Functional_Classification immunoglobulins
Cellular_Localization Extracellular
Gene_Names IGHE
UniProt_ID P01855
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name P124 (heated IgE)
Peptide_Sequence YVFLPPEEEEKRYR
Peptide_Length 14
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1855.08
Aliphatic_Index 48.57143
Aromaticity 0.21429
Average_Rotatable_Bonds 4.14286
Charge_at_pH_7 -0.99692
Isoelectric_Point 4.62819
Number_of_Hydrogen_Bond_Acceptors 24
Number_of_Hydrogen_Bond_Donors 26
Topological_Polar_Surface_Area 763.52000
X_logP_energy -3.33076
Interaction Information
Affinity IC50=0.14 uM
Affinity_Assay ELISA
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Use of synthetic peptides in the production and characterization of antibodies directed against predetermined specificities in rat immunoglobulin E
Release_Year 1986
PMID 3702875
DOI 10.1016/0161-5890(86)90041-6