PPIRE15244
Target Protein Information
| Protein_Name | Neutrophil gelatinase-associated lipocalin |
|---|---|
| Protein_Sequence | MPLGLLWLGLALLGALHAQAQDSTSDLIPAPPLSKVPLQQNFQDNQFQGKWYVVGLAGNAILREDKDPQKMYATIYELKEDKSYNVTSVLFRKKKCDYWIRTFVPGCQPGEFTLGNIKSYPGLTSYLVRVVSTNYNQHAMVFFKKVSQNREYFKITLYGRTKELTSELKENFIRFSKSLGLPENHIVFPVPIDQCIDG |
| Organism_Source | Homo sapiens |
| Functional_Classification | Lipocalins |
| Cellular_Localization | Extracellular |
| Gene_Names | LCN2 |
| UniProt_ID | P80188 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Au167 |
|---|---|
| Peptide_Sequence | KLVFFAEDVGSN |
| Peptide_Length | 12 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)O)C(C)C)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1325.48 |
|---|---|
| Aliphatic_Index | 89.16667 |
| Aromaticity | 0.16667 |
| Average_Rotatable_Bonds | 3.58333 |
| Charge_at_pH_7 | -1.00009 |
| Isoelectric_Point | 4.18441 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 18 |
| Number_of_Hydrogen_Bond_Donors | 18 |
| Topological_Polar_Surface_Area | 547.36000 |
| X_logP_energy | -4.43790 |
Interaction Information
| Affinity | KD=2.75 nM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer u-amyloid peptide |
| Release_Year | 2016 |
| PMID | 27029347 |
| DOI | 10.1042/BCJ20160114 |