PPIRE15246

Target Protein Information
Protein_Name Heterochromatin protein 1
Protein_Sequence MGKKIDNPESSAKVSDAEEEEEEYAVEKIIDRRVRKGKVEYYLKWKGYPETENTWEPENNLDCQDLIQQYEASRKDEEKSAASKKDRPSSSAKAKETQGRASSSTSTASKRKSEEPTAPSGNKSKRTTDAEQDTIPVSGSTGFDRGLEAEKILGASDNNGRLTFLIQFKGVDQAEMVPSSVANEKIPRMVIHFYEERLSWYSDNED
Organism_Source Drosophila melanogaster
Functional_Classification heterochromatin protein
Cellular_Localization Nucleus
Gene_Names Su(var)205
UniProt_ID P05205
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HP2 peptide
Peptide_Sequence QNISPRKLCVKINRRPYNKWLR
Peptide_Length 22
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)CC)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2783.34
Aliphatic_Index 84.09091
Aromaticity 0.09091
Average_Rotatable_Bonds 4.22727
Charge_at_pH_7 6.93426
Isoelectric_Point 12.10661
Number_of_Hydrogen_Bond_Acceptors 37
Number_of_Hydrogen_Bond_Donors 44
Topological_Polar_Surface_Area 1211.11000
X_logP_energy -10.64192
Interaction Information
Affinity KD=0.3 uM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title The HP1a Disordered C Terminus and Chromo Shadow Domain Cooperate to Select Target Peptide Partners
Release_Year 2011
PMID 21472955
DOI 10.1002/cbic.201000598