PPIRE15247

Target Protein Information
Protein_Name Heterochromatin protein 1
Protein_Sequence MGKKIDNPESSAKVSDAEEEEEEYAVEKIIDRRVRKGKVEYYLKWKGYPETENTWEPENNLDCQDLIQQYEASRKDEEKSAASKKDRPSSSAKAKETQGRASSSTSTASKRKSEEPTAPSGNKSKRTTDAEQDTIPVSGSTGFDRGLEAEKILGASDNNGRLTFLIQFKGVDQAEMVPSSVANEKIPRMVIHFYEERLSWYSDNED
Organism_Source Drosophila melanogaster
Functional_Classification heterochromatin protein
Cellular_Localization Nucleus
Gene_Names Su(var)205
UniProt_ID P05205
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PIWI peptide
Peptide_Sequence TSRGSGDPRVKVFRGSSSGDY
Peptide_Length 21
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2215.37
Aliphatic_Index 27.61905
Aromaticity 0.09524
Average_Rotatable_Bonds 3.42857
Charge_at_pH_7 1.99772
Isoelectric_Point 10.43830
Number_of_Hydrogen_Bond_Acceptors 35
Number_of_Hydrogen_Bond_Donors 40
Topological_Polar_Surface_Area 1064.46000
X_logP_energy -17.16039
Interaction Information
Affinity KD=20 uM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title The HP1a Disordered C Terminus and Chromo Shadow Domain Cooperate to Select Target Peptide Partners
Release_Year 2011
PMID 21472955
DOI 10.1002/cbic.201000598