PPIRE15267

Target Protein Information
Protein_Name cAMP-dependent protein kinase catalytic subunit alpha
Protein_Sequence MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
Organism_Source Bos taurus
Functional_Classification serine threonine protein kinase
Cellular_Localization Cytoplasm
Gene_Names PRKACA
UniProt_ID P00517
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name [Ala30]histone H2B(29-35)
Peptide_Sequence RARSRKE
Peptide_Length 7
Peptide_SMILES C[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 902.02
Aliphatic_Index 14.28571
Aromaticity 0.00000
Average_Rotatable_Bonds 4.71429
Charge_at_pH_7 2.99945
Isoelectric_Point 12.22264
Number_of_Hydrogen_Bond_Acceptors 14
Number_of_Hydrogen_Bond_Donors 20
Topological_Polar_Surface_Area 507.17000
X_logP_energy -6.89709
Interaction Information
Affinity KD=17.3 pM
Affinity_Assay fluorescence anisotropy titration
PDB_ID None
Type Substrate
Structure
Reference Information
Document_Type Research Articles
Title Synthetic peptide analogues differentially alter the binding affinities of cyclic nucleotide dependent protein kinases for nucleotide substrates
Release_Year 1988
PMID 2837278
DOI 10.1021/bi00406a027