PPIRE15273

Target Protein Information
Protein_Name Ig gamma-1 chain C region secreted form/Immunoglobulin kappa constant
Protein_Sequence AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMNTNGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK/RADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC
Organism_Source Mus musculus/Mus musculus
Functional_Classification monoclonal antibody
Cellular_Localization Extracellular
Gene_Names Ighg1/Igkc
UniProt_ID P01868/P01837
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name FLAG peptide
Peptide_Sequence DYKDDDDK
Peptide_Length 8
Peptide_SMILES NCCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1012.98
Aliphatic_Index 0.00000
Aromaticity 0.12500
Average_Rotatable_Bonds 4.37500
Charge_at_pH_7 -3.00122
Isoelectric_Point 3.85108
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 17
Topological_Polar_Surface_Area 525.79000
X_logP_energy -5.62830
Interaction Information
Affinity KD=3.3 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Affinity of the monoclonal antibody M1 directed against the FLAG peptide
Release_Year 2001
PMID 11461009
DOI 10.1016/S0021-9673(01)00831-7