PPIRE15322

Target Protein Information
Protein_Name Pro-glucagon
Protein_Sequence MKSIYFVAGLFVMLVQGSWQRSLQDTEEKSRSFSASQADPLSDPDQMNEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVAIVEELGRRHADGSFSDEMNTILDNLAARDFINWLIQTKITDRK
Organism_Source Homo sapiens
Functional_Classification peptide hormones
Cellular_Localization Extracellular
Gene_Names GCG
UniProt_ID P01275
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name shuf (R-K fix) 2
Peptide_Sequence RWFKIQMQIRRWKNKK
Peptide_Length 16
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)CC)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2246.75
Aliphatic_Index 48.75000
Aromaticity 0.18750
Average_Rotatable_Bonds 5.00000
Charge_at_pH_7 6.99679
Isoelectric_Point 12.82564
Number_of_Hydrogen_Bond_Acceptors 28
Number_of_Hydrogen_Bond_Donors 35
Topological_Polar_Surface_Area 950.45000
X_logP_energy -5.08149
Interaction Information
Affinity KD=64.3 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title The role of intermolecular interactions with penetratin and its analogue on the enhancement of absorption of nasal therapeutic peptides
Release_Year 2010
PMID 20060451
DOI 10.1016/j.ijpharm.2009.12.060