PPIRE15365
Target Protein Information
| Protein_Name | Alpha-synuclein |
|---|---|
| Protein_Sequence | MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA |
| Organism_Source | Homo sapiens |
| Functional_Classification | amyloid proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | SNCA |
| UniProt_ID | P37840 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | a-syn(11932) |
|---|---|
| Peptide_Sequence | DPDNEAYEMPSEEG |
| Peptide_Length | 14 |
| Peptide_SMILES | CSCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1582.57 |
|---|---|
| Aliphatic_Index | 7.14286 |
| Aromaticity | 0.07143 |
| Average_Rotatable_Bonds | 3.50000 |
| Charge_at_pH_7 | -5.99487 |
| Isoelectric_Point | 3.16720 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 25 |
| Number_of_Hydrogen_Bond_Donors | 22 |
| Topological_Polar_Surface_Area | 731.39000 |
| X_logP_energy | -8.65790 |
Interaction Information
| Affinity | KD=16 uM |
|---|---|
| Affinity_Assay | Isothermal Titration Calorimetry |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Phosphorylation-dependent metal binding by u-synuclein peptide fragments |
| Release_Year | 2006 |
| PMID | 17082919 |
| DOI | 10.1007/s00775-006-0181-y |