PPIRE15367

Target Protein Information
Protein_Name L-lactate dehydrogenase B chain
Protein_Sequence MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
Organism_Source Homo sapiens
Functional_Classification dehydrogenases
Cellular_Localization Cytoplasm
Gene_Names LDHB
UniProt_ID P07195
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name LP-22
Peptide_Sequence LEDKLKGEMMDLQHGSLFLQTP
Peptide_Length 22
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2530.94
Aliphatic_Index 88.63636
Aromaticity 0.04545
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 -1.90725
Isoelectric_Point 4.53867
Number_of_Hydrogen_Bond_Acceptors 36
Number_of_Hydrogen_Bond_Donors 33
Topological_Polar_Surface_Area 1022.19000
X_logP_energy -7.86560
Interaction Information
Affinity KD=156 uM
Affinity_Assay Microscale Thermophoresis
PDB_ID None
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title Discovery of a novel lactate dehydrogenase tetramerization domain using epitope mapping and peptides
Release_Year 2021
PMID 33607109
DOI 10.1016/j.jbc.2021.100422