PPIRE15368

Target Protein Information
Protein_Name L-lactate dehydrogenase B chain
Protein_Sequence MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
Organism_Source Homo sapiens
Functional_Classification dehydrogenases
Cellular_Localization Cytoplasm
Gene_Names LDHB
UniProt_ID P07195
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name GP-16
Peptide_Sequence GEMMDLQHGSLFLQTP
Peptide_Length 16
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)CN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1804.07
Aliphatic_Index 73.12500
Aromaticity 0.06250
Average_Rotatable_Bonds 3.68750
Charge_at_pH_7 -1.90889
Isoelectric_Point 4.18115
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 720.95000
X_logP_energy -6.46410
Interaction Information
Affinity KD=240 uM
Affinity_Assay Microscale Thermophoresis
PDB_ID None
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title Discovery of a novel lactate dehydrogenase tetramerization domain using epitope mapping and peptides
Release_Year 2021
PMID 33607109
DOI 10.1016/j.jbc.2021.100422