PPIRE15400

Target Protein Information
Protein_Name Gap junction alpha-1 protein
Protein_Sequence MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNVEMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKGRSDPYHATTGPLSPSKDCGSPKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDNQNAKKVAAGHELQPLAIVDQRPSSRASSRASSRPRPDDLEI
Organism_Source Rattus norvegicus
Functional_Classification gap junction channel
Cellular_Localization Plasma membrane
Gene_Names Gja1
UniProt_ID P08050
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name P18095
Peptide_Sequence SLSAVYTCKRDPCPHQ
Peptide_Length 16
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)O)[C@@H](C)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1805.06
Aliphatic_Index 48.75000
Aromaticity 0.06250
Average_Rotatable_Bonds 3.37500
Charge_at_pH_7 0.96424
Isoelectric_Point 8.23279
Number_of_Hydrogen_Bond_Acceptors 28
Number_of_Hydrogen_Bond_Donors 28
Topological_Polar_Surface_Area 760.15000
X_logP_energy -9.32373
Interaction Information
Affinity IC50=500 uM
Affinity_Assay Patch-clamp electrophysiology
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Selective inhibition of gap junction channel activity by synthetic peptides
Release_Year 1999
PMID 10200417
DOI 10.1111/j.1469-7793.1999.0679u.x