PPIRE15401

Target Protein Information
Protein_Name Gap junction alpha-5 protein
Protein_Sequence MGDWSFLGEFLEEVHKHSTVIGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPGCQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKQKLREAEKAKEAGGTGTYEYLAEKAELSCWKEVNGKIVLQGTLLNTYVCTILIRTAMEVAFMVGQYLLYGIFLDTLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMMAVAGLSLFLSLAELYHLGWKKIRQRLAKSRQGDKHQLLGPSTSLVQGLTPPPDFNQCLKNSPDEKFFSDFSNNMGSRKNPDPLATEEVPNQEQIPEEGFIHTQYGQKPEQPSGASAGHRFPQGYHSDKRRLSKASSKARSDDLSV
Organism_Source Rattus norvegicus
Functional_Classification gap junction channel
Cellular_Localization Plasma membrane
Gene_Names Gja5
UniProt_ID P28234
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name P17792
Peptide_Sequence FLDTLHVCRRSPCPHP
Peptide_Length 16
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1878.20
Aliphatic_Index 66.87500
Aromaticity 0.06250
Average_Rotatable_Bonds 3.31250
Charge_at_pH_7 1.05629
Isoelectric_Point 8.25383
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 27
Topological_Polar_Surface_Area 732.37000
X_logP_energy -6.65466
Interaction Information
Affinity IC50=50 uM
Affinity_Assay Patch-clamp electrophysiology
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Selective inhibition of gap junction channel activity by synthetic peptides
Release_Year 1999
PMID 10200417
DOI 10.1111/j.1469-7793.1999.0679u.x