PPIRE15402

Target Protein Information
Protein_Name Cysteine-rich secretory protein 2
Protein_Sequence MALLPVLFLVTVLLPSLPAEGKDPAFTALLTTQLQVQREIVNKHNELRKAVSPPASNMLKMEWSREVTTNAQRWANKCTLQHSDPEDRKTSTRCGENLYMSSDPTSWSSAIQSWYDEILDFVYGVGPKSPNAVVGHYTQLVWYSTYQVGCGIAYCPNQDSLKYYYVCQYCPAGNNMNRKNTPYQQGTPCAGCPDDCDKGLCTNSCQYQDLLSNCDSLKNTAGCEHELLKEKCKATCLCENKIY
Organism_Source Homo sapiens
Functional_Classification CRISP superfamily
Cellular_Localization Extracellular
Gene_Names CRISP2
UniProt_ID P16562
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name tpx-1-#1
Peptide_Sequence QLQVQREIVNKHNELR
Peptide_Length 16
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCC(N)=O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2004.28
Aliphatic_Index 109.37500
Aromaticity 0.00000
Average_Rotatable_Bonds 4.50000
Charge_at_pH_7 1.09214
Isoelectric_Point 9.69216
Number_of_Hydrogen_Bond_Acceptors 28
Number_of_Hydrogen_Bond_Donors 32
Topological_Polar_Surface_Area 968.37000
X_logP_energy -9.98116
Interaction Information
Affinity IC50=1 nM
Affinity_Assay ELISA
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Synthesis and application of peptide immunogens related to the sperm tail protein tpx-1 a member of the CRISP superfamily of proteins
Release_Year 2001
PMID 11168883
DOI 10.1034/j.1399-3011.2001.00779.x