PPIRE15403
Target Protein Information
| Protein_Name | Cysteine-rich secretory protein 2 |
|---|---|
| Protein_Sequence | MALLPVLFLVTVLLPSLPAEGKDPAFTALLTTQLQVQREIVNKHNELRKAVSPPASNMLKMEWSREVTTNAQRWANKCTLQHSDPEDRKTSTRCGENLYMSSDPTSWSSAIQSWYDEILDFVYGVGPKSPNAVVGHYTQLVWYSTYQVGCGIAYCPNQDSLKYYYVCQYCPAGNNMNRKNTPYQQGTPCAGCPDDCDKGLCTNSCQYQDLLSNCDSLKNTAGCEHELLKEKCKATCLCENKIY |
| Organism_Source | Homo sapiens |
| Functional_Classification | CRISP superfamily |
| Cellular_Localization | Extracellular |
| Gene_Names | CRISP2 |
| UniProt_ID | P16562 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | tpx-1-#2 |
|---|---|
| Peptide_Sequence | TPYQQGTPCACA |
| Peptide_Length | 12 |
| Peptide_SMILES | C[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)[C@@H](C)O)[C@@H](C)O)C(=O)O |
| Chemical_Modification | C9=Acm |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1239.38 |
|---|---|
| Aliphatic_Index | 16.66667 |
| Aromaticity | 0.08333 |
| Average_Rotatable_Bonds | 2.75000 |
| Charge_at_pH_7 | -0.12682 |
| Isoelectric_Point | 5.82405 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 20 |
| Number_of_Hydrogen_Bond_Donors | 18 |
| Topological_Polar_Surface_Area | 512.71000 |
| X_logP_energy | -7.48480 |
Interaction Information
| Affinity | IC50=8 nM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Synthesis and application of peptide immunogens related to the sperm tail protein tpx-1 a member of the CRISP superfamily of proteins |
| Release_Year | 2001 |
| PMID | 11168883 |
| DOI | 10.1034/j.1399-3011.2001.00779.x |