PPIRE15404

Target Protein Information
Protein_Name Cysteine-rich secretory protein 2
Protein_Sequence MALLPVLFLVTVLLPSLPAEGKDPAFTALLTTQLQVQREIVNKHNELRKAVSPPASNMLKMEWSREVTTNAQRWANKCTLQHSDPEDRKTSTRCGENLYMSSDPTSWSSAIQSWYDEILDFVYGVGPKSPNAVVGHYTQLVWYSTYQVGCGIAYCPNQDSLKYYYVCQYCPAGNNMNRKNTPYQQGTPCAGCPDDCDKGLCTNSCQYQDLLSNCDSLKNTAGCEHELLKEKCKATCLCENKIY
Organism_Source Homo sapiens
Functional_Classification CRISP superfamily
Cellular_Localization Extracellular
Gene_Names CRISP2
UniProt_ID P16562
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name tpx-1-#3
Peptide_Sequence AGCEHELLKEKCKAT
Peptide_Length 15
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CS)NC(=O)CNC(=O)[C@H](C)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)O)[C@@H](C)O
Chemical_Modification C3=Acm; C12=Acm
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1659.94
Aliphatic_Index 65.33333
Aromaticity 0.00000
Average_Rotatable_Bonds 3.93333
Charge_at_pH_7 -0.03062
Isoelectric_Point 7.25515
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 26
Topological_Polar_Surface_Area 709.59000
X_logP_energy -6.86350
Interaction Information
Affinity IC50=200 nM
Affinity_Assay ELISA
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Synthesis and application of peptide immunogens related to the sperm tail protein tpx-1 a member of the CRISP superfamily of proteins
Release_Year 2001
PMID 11168883
DOI 10.1034/j.1399-3011.2001.00779.x