PPIRE15415

Target Protein Information
Protein_Name Advanced glycosylation end product-specific receptor
Protein_Sequence MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP
Organism_Source Homo sapiens
Functional_Classification pattern recognition receptor
Cellular_Localization Extracellular
Gene_Names AGER
UniProt_ID Q15109
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PA #103
Peptide_Sequence IQLRVRMKLV
Peptide_Length 10
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)O)C(C)C)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1255.63
Aliphatic_Index 175.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 4.50000
Charge_at_pH_7 2.99768
Isoelectric_Point 12.51648
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 19
Topological_Polar_Surface_Area 518.13000
X_logP_energy -2.11406
Interaction Information
Affinity KD=1 uM
Affinity_Assay ELISA
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Combinatorial Library of Improved Peptide Aptamers CLIPs to Inhibit RAGE Signal Transduction in Mammalian Cells
Release_Year 2013
PMID 23785412
DOI 10.1371/journal.pone.0065180