PPIRE15436

Target Protein Information
Protein_Name Lysosomal-associated transmembrane protein 4B
Protein_Sequence MTSRTRVTWPSPPRPLPVPAAAAVAFGAKGTDPAEARSSRGIEEAGPRAHGRAGREPERRRSRQQRRGGLQARRSTLLKTCARARATAPGAMKMVAPWTRFYSNSCCLCCHVRTGTILLGVWYLIINAVVLLILLSALADPDQYNFSSSELGGDFEFMDDANMCIAIAISLLMILICAMATYGAYKQRAAWIIPFFCYQIFDFALNMLVAITVLIYPNSIQEYIRQLPPNFPYRDDVMSVNPTCLVLIILLFISIILTFKGYLISCVWNCYRYINGRNSSDVLVYVTSNDTTVLLPPYDDATVNGAAKEPPPPYVSA
Organism_Source Homo sapiens
Functional_Classification Accessory factors lysosomal associated membrane proteins
Cellular_Localization Lysosome
Gene_Names LAPTM4B
UniProt_ID Q86VI4
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name LAP2H
Peptide_Sequence GGGRDNIHGHHIISVG
Peptide_Length 16
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)NCC(=O)O)C(C)C)[C@@H](C)CC)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1625.77
Aliphatic_Index 91.25000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.31250
Charge_at_pH_7 0.27115
Isoelectric_Point 7.81118
Number_of_Hydrogen_Bond_Acceptors 24
Number_of_Hydrogen_Bond_Donors 26
Topological_Polar_Surface_Area 748.38000
X_logP_energy -9.87533
Interaction Information
Affinity KD=11.9 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Noninvasively visualize the expression of LAPTM4B protein using a novel 18F-labeled peptide PET probe in hepatocellular carcinoma
Release_Year 2021
PMID 34214768
DOI 10.1016/j.nucmedbio.2021.06.003