PPIRE15470

Target Protein Information
Protein_Name Nucleophosmin
Protein_Sequence MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEDEEDVKLLGMSGKRSAPGGGNKVPQKKVKLDEDDDEDDEDDEDDEDDDDDDFDEEETEEKVPVKKSVRDTPAKNAQKSNQNGKDLKPSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL
Organism_Source Rattus norvegicus
Functional_Classification nuclear import receptors
Cellular_Localization Nucleus
Gene_Names Npm1
UniProt_ID P13084
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Rev37-47
Peptide_Sequence ARRNRRRRWREYC
Peptide_Length 13
Peptide_SMILES C[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1878.15
Aliphatic_Index 7.69231
Aromaticity 0.15385
Average_Rotatable_Bonds 4.84615
Charge_at_pH_7 5.93691
Isoelectric_Point 12.37647
Number_of_Hydrogen_Bond_Acceptors 25
Number_of_Hydrogen_Bond_Donors 40
Topological_Polar_Surface_Area 962.23000
X_logP_energy -10.57901
Interaction Information
Affinity KD=0.082 uM
Affinity_Assay equilibrium dialysis
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Interaction of Nucleolar Protein B23 with Peptides Related to Nuclear Localization Signals
Release_Year 1995
PMID None
DOI 10.1021/bi9502710