PPIRE15659
Target Protein Information
| Protein_Name | Putative histone H1.9 |
|---|---|
| Protein_Sequence | MLHASTIWHLRSTPPRRKQWGHCDPHRILVASEVTTEITSPTPAPRAQVCGGQPWVTVLDPLSGHTGREAERHFATVSISAVELKYCHGWRPAGQRVPSKTATGQRTCAKPCQKPSTSKVILRAVADKGTCKYVSLATLKKAVSTTGYDMARNAYHFKRVLKGLVDKGSAGSFTLGKKQASKSKLKVKRQRQQRWRSGQRPFGQHRSLLGSKQGHKRLIKGVRRVAKCHCN |
| Organism_Source | Homo sapiens |
| Functional_Classification | histones |
| Cellular_Localization | Nucleus |
| Gene_Names | H1-9P |
| UniProt_ID | P60008 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Linker-free heterodimer peptide (histone H1) |
|---|---|
| Peptide_Sequence | CQRPPRRRLLVM |
| Peptide_Length | 12 |
| Peptide_SMILES | CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CS)C(C)C)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1524.91 |
|---|---|
| Aliphatic_Index | 89.16667 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 4.08333 |
| Charge_at_pH_7 | 3.93600 |
| Isoelectric_Point | 12.50010 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 20 |
| Number_of_Hydrogen_Bond_Donors | 25 |
| Topological_Polar_Surface_Area | 656.53000 |
| X_logP_energy | -5.50682 |
Interaction Information
| Affinity | KD=6.1 mM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Conversion of Low-Affinity Peptides to High-Affinity Peptide Binders by Using a b-Hairpin Scaffold-Assisted Approach |
| Release_Year | 2014 |
| PMID | 25371172 |
| DOI | 10.1002/cbic.201402450 |