PPIRE15674

Target Protein Information
Protein_Name Calcitonin receptor
Protein_Sequence MRFTFTSRCLALFLLLNHPTPILPAFSNQTYPTIEPKPFLYVVGRKKMMDAQYKCYDRMQQLPAYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFPDFDPSEKVTKYCDEKGVWFKHPENNRTWSNYTMCNAFTPEKLKNAYVLYYLAIVGHSLSIFTLVISLGIFVFFRSLGCQRVTLHKNMFLTYILNSMIIIIHLVEVVPNGELVRRDPVSCKILHFFHQYMMACNYFWMLCEGIYLHTLIVVAVFTEKQRLRWYYLLGWGFPLVPTTIHAITRAVYFNDNCWLSVETHLLYIIHGPVMAALVVNFFFLLNIVRVLVTKMRETHEAESHMYLKAVKATMILVPLLGIQFVVFPWRPSNKMLGKIYDYVMHSLIHFQGFFVATIYCFCNNEVQTTVKRQWAQFKIQWNQRWGRRPSNRSARAAAAAAEAGDIPIYICHQELRNEPANNQGEESAEIIPLNIIEQESSA
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names CALCR
UniProt_ID P30988
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name FITC-sCT(222)
Peptide_Sequence YPRTNTGSGTP
Peptide_Length 11
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification FITC-Ahx
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1150.21
Aliphatic_Index 0.00000
Aromaticity 0.09091
Average_Rotatable_Bonds 2.81818
Charge_at_pH_7 0.99713
Isoelectric_Point 9.34881
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 19
Topological_Polar_Surface_Area 542.88000
X_logP_energy -9.25683
Interaction Information
Affinity KD=0.84 uM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Asn-linked Ncetylglucosamine of the amylin receptor 2 extracellular domain enhances peptide ligand affinity
Release_Year 2020
PMID 33227824
DOI 10.1002/2211-5463.13042