PPIRE15710
Target Protein Information
| Protein_Name | Telomeric repeat-binding factor 2-interacting protein 1 |
|---|---|
| Protein_Sequence | MAEAMDLGKDPNGPTHSSTLFVRDDGSSMSFYVRPSPAKRRLSTLILHGGGTVCRVQEPGAVLLAQPGEALAEASGDFISTQYILDCVERNERLELEAYRLGPASAADTGSEAKPGALAEGAAEPEPQRHAGRIAFTDADDVAILTYVKENARSPSSVTGNALWKAMEKSSLTQHSWQSLKDRYLKHLRGQEHKYLLGDAPVSPSSQKLKRKAEEDPEAADSGEPQNKRTPDLPEEEYVKEEIQENEEAVKKMLVEATREFEEVVVDESPPDFEIHITMCDDDPPTPEEDSETQPDEEEEEEEEKVSQPEVGAAIKIIRQLMEKFNLDLSTVTQAFLKNSGELEATSAFLASGQRADGYPIWSRQDDIDLQKDDEDTREALVKKFGAQNVARRIEFRKK |
| Organism_Source | Homo sapiens |
| Functional_Classification | telomere binding proteins |
| Cellular_Localization | Nucleus |
| Gene_Names | TERF2IP |
| UniProt_ID | Q9NYB0 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Peptide 19 |
|---|---|
| Peptide_Sequence | TTIGXTLKXAFKTLS |
| Peptide_Length | 15 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)O)[C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O)[C@@H](C)O |
| Chemical_Modification | X286=azide; X290=alkyne |
| Cyclization_Method | Side chain-side chain cyclization; 286<-->290; other bonds |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Acetyl |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1494.75 |
|---|---|
| Aliphatic_Index | 84.66667 |
| Aromaticity | 0.06667 |
| Average_Rotatable_Bonds | 3.33333 |
| Charge_at_pH_7 | 1.99739 |
| Isoelectric_Point | 10.80538 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 23 |
| Number_of_Hydrogen_Bond_Donors | 23 |
| Topological_Polar_Surface_Area | 623.91000 |
| X_logP_energy | -7.74590 |
Interaction Information
| Affinity | Ki=32 nM |
|---|---|
| Affinity_Assay | Fluorescence Polarization |
| PDB_ID | 3K6G |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Design of High-Affinity Stapled Peptides To Target the Repressor Activator Protein 1 (RAP1)/Telomeric Repeat-Binding Factor 2 (TRF2) Protein-1rotein Interaction in the Shelterin Complex |
| Release_Year | 2016 |
| PMID | 26673461 |
| DOI | 10.1021/acs.jmedchem.5b01465 |