PPIRE15719

Target Protein Information
Protein_Name Plasminogen activator inhibitor 1
Protein_Sequence MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
Organism_Source Homo sapiens
Functional_Classification serine protease inhibitors
Cellular_Localization Extracellular
Gene_Names SERPINE1
UniProt_ID P05121
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name BP6
Peptide_Sequence KKQRFRHRNRKGYRSQ
Peptide_Length 16
Peptide_SMILES N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2145.46
Aliphatic_Index 0.00000
Aromaticity 0.12500
Average_Rotatable_Bonds 4.87500
Charge_at_pH_7 8.08714
Isoelectric_Point 12.69088
Number_of_Hydrogen_Bond_Acceptors 31
Number_of_Hydrogen_Bond_Donors 41
Topological_Polar_Surface_Area 1085.79000
X_logP_energy -13.43945
Interaction Information
Affinity IC50=50 nM
Affinity_Assay ELISA
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Research Articles
Title The cluster of basic amino acids in vitronectin contributes to its binding of plasminogen activator inhibitor-1: evidence from thrombin- elastase- and plasmin-cleaved vitronectins and anti-peptide antibodies
Release_Year 1997
PMID 9230112
DOI 10.1042/bj3250339