PPIRE15733

Target Protein Information
Protein_Name Connector enhancer of kinase suppressor of ras 3
Protein_Sequence MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKAPNEFLTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCFVAEMEDKVLTVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFTPAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYSPRDENGSFVYGGSSKCKQPLPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILPTKMREKTPSYGKPRPLSMPADGNWMGIVDPFARPRGHGRKGEDALCRYFSNERIPPIIEESSSPPYRFSRPTTERHLVRGADYIRGSRCYINSDLHSSATIPFQEEGTKKKSGSSATKSSSTEPSLLVSWFTRLKLLTH
Organism_Source Homo sapiens
Functional_Classification Adaptor scaffold proteins
Cellular_Localization Plasma membrane
Gene_Names CNKSR3
UniProt_ID Q6P9H4
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name 16E6ct L0 V
Peptide_Sequence RSSRTRRETQV
Peptide_Length 11
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)O)[C@@H](C)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1375.51
Aliphatic_Index 26.36364
Aromaticity 0.00000
Average_Rotatable_Bonds 4.36364
Charge_at_pH_7 2.99975
Isoelectric_Point 12.50005
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 30
Topological_Polar_Surface_Area 763.23000
X_logP_energy -12.16812
Interaction Information
Affinity KD=0.99 uM
Affinity_Assay Isothermal Titration Calorimetry
PDB_ID 2KPL
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Disorder-To-Order Transition of MAGI-1 PDZ1 C-Terminal Extension upon Peptide Binding: Thermodynamic and Dynamic Insights
Release_Year 2015
PMID 25590897
DOI 10.1021/bi500845j