PPIRE15776

Target Protein Information
Protein_Name Paired immunoglobulin-like type 2 receptor alpha
Protein_Sequence MGRPLLLPLLPLLLPPAFLQPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHRQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSITQAVTTTTQRPSSMTTTWRLSSTTTTTGLRVTQGKRRSDSWHISLETAVGVAVAVTVLGIMILGLICLLRWRRRKGQQRTKATTPAREPFQNTEEPYENIRNEGQNTDPKLNPKDDGIVYASLALSSSTSPRAPPSHRPLKSPQNETLYSVLKA
Organism_Source Homo sapiens
Functional_Classification immunoglobulin like receptors
Cellular_Localization Plasma membrane
Gene_Names PILRA
UniProt_ID Q9UKJ1
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name mCD99 glycopeptide (residues 420)
Peptide_Sequence MKPTPKAPT
Peptide_Length 9
Peptide_SMILES CSCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification T4=Neu5Acu2-6GalNAc
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 970.20
Aliphatic_Index 11.11111
Aromaticity 0.00000
Average_Rotatable_Bonds 3.00000
Charge_at_pH_7 1.99739
Isoelectric_Point 10.80538
Number_of_Hydrogen_Bond_Acceptors 15
Number_of_Hydrogen_Bond_Donors 11
Topological_Polar_Surface_Area 362.25000
X_logP_energy -3.41210
Interaction Information
Affinity KD=2.8 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID 3WV0
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILRu
Release_Year 2014
PMID 24889612
DOI 10.1073/pnas.1324105111