PPIRE15791

Target Protein Information
Protein_Name IgG receptor FcRn large subunit p51
Protein_Sequence MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLVVGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNVIPATA
Organism_Source Homo sapiens
Functional_Classification Fc receptor
Cellular_Localization Plasma membrane
Gene_Names FCGRT
UniProt_ID P55899
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SYN723
Peptide_Sequence GGGCVTGHFGGIYCNYQ
Peptide_Length 17
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)CNC(=O)CNC(=O)CN)C(C)C)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method Side chainide chain cyclization; C4<-->C16; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1732.91
Aliphatic_Index 40.00000
Aromaticity 0.17647
Average_Rotatable_Bonds 3.05882
Charge_at_pH_7 -0.03676
Isoelectric_Point 7.24864
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 26
Topological_Polar_Surface_Area 704.47000
X_logP_energy -8.86800
Interaction Information
Affinity KD=5.2 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Research Articles
Title Structurectivity relationships of a peptide inhibitor of the human FcRn:human IgG interaction
Release_Year 2008
PMID 18501614
DOI 10.1016/j.bmc.2008.05.004