PPIRE15794

Target Protein Information
Protein_Name IgG receptor FcRn large subunit p51
Protein_Sequence MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLVVGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNVIPATA
Organism_Source Homo sapiens
Functional_Classification Fc receptor
Cellular_Localization Plasma membrane
Gene_Names FCGRT
UniProt_ID P55899
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SYN724
Peptide_Sequence KIICSPGHFGGMYCQGK
Peptide_Length 17
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)[C@@H](C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method Side chainide chain cyclization; C4<-->C16; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1826.18
Aliphatic_Index 45.88235
Aromaticity 0.11765
Average_Rotatable_Bonds 3.47059
Charge_at_pH_7 1.96350
Isoelectric_Point 8.79541
Number_of_Hydrogen_Bond_Acceptors 27
Number_of_Hydrogen_Bond_Donors 25
Topological_Polar_Surface_Area 684.40000
X_logP_energy -6.43560
Interaction Information
Affinity KD=22 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Research Articles
Title Structurectivity relationships of a peptide inhibitor of the human FcRn:human IgG interaction
Release_Year 2008
PMID 18501614
DOI 10.1016/j.bmc.2008.05.004