PPIRE15799

Target Protein Information
Protein_Name IgG receptor FcRn large subunit p51
Protein_Sequence MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLVVGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNVIPATA
Organism_Source Homo sapiens
Functional_Classification Fc receptor
Cellular_Localization Plasma membrane
Gene_Names FCGRT
UniProt_ID P55899
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SYN726
Peptide_Sequence NSFCRGRPGHFGGCYLF
Peptide_Length 17
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Chemical_Modification None
Cyclization_Method Side chainide chain cyclization; C4<-->C13; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1918.18
Aliphatic_Index 22.94118
Aromaticity 0.23529
Average_Rotatable_Bonds 3.35294
Charge_at_pH_7 1.96409
Isoelectric_Point 8.80680
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 756.16000
X_logP_energy -7.87096
Interaction Information
Affinity IC50=33 uM
Affinity_Assay ELISA
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Research Articles
Title Structurectivity relationships of a peptide inhibitor of the human FcRn:human IgG interaction
Release_Year 2008
PMID 18501614
DOI 10.1016/j.bmc.2008.05.004