PPIRE15804
Target Protein Information
| Protein_Name | G-protein coupled receptor family C group 6 member A |
|---|---|
| Protein_Sequence | MALLITVVTCFMIILDTSQSCHTPDDFVAITSPGHIMIGGLFAIHEKMLSSDDHPRRPQIQKCAGFEISVFLQTLAMIHSIEMINNSTLLSGVKLGYEIYDTCTEVTAAMAATLRFLSKFNCSRETVVFQCDYSSYMPRVKAVIGAGYSETSIAVSRMLNLQLMPQVSYESTAEILSDKIRFPSFLRTVPSDFYQTKAMAHLIRQSGWNWIGAITTDDDYGRLALNTFAIQAAENNVCIAFKEVLPAFLSDNTIEVRINQTLEKIIAEAQVNVIVVFLRKFHVFNLFTKAIERKISKIWIASDNWSTATKIITIPNVKKLGKVVGFAFRRGNTSSFHSFLQTLHMYPNDNNKPLHEFAMLVSACKYIKDGDLSQCISNYSQATLTYDTTKTIENHLFKRNDFLWHYTEPGLIYSIQLAVFALGHAIRDLCQARDCKKPNAFQPWELLAVLKNVTFTDGRNSFHFDAHGDLNTGYDVVLWKETNGLMTVTKMAEYDLQRDVFITTNQETKHEFRKLKQILSKCSKECSPGQMKKATGSQHSCCYECVSCPENHYSNETDMDHCLLCNNETHWAPVRSTTCFEKEVEYLDWDDSLALLLIALSLLGIAFVLAIGIIFTRNLKTPVVKSSGGLVVCYVMLICHALNFASTGFFIGEPQDFACKTRQTLFGVSFTLCVSCILTKSLKILLAFSFDPKLTMFLKCLYRPVPIVLTCTGIQVVICTLWLVLAAPSVEENISLPRVIILECEEGSALAFGTMLGYITVLAFICFVFAFKGRKLPENYNEAKFLTFGMLIYFIAWITFIPVYTTTFGKYLPAVEIIVILISNYGILCCIFFPKCYIILCKQKTNTKSAFLQMVYNYSAHSVDSLALSHVSLDSTSYDTATTNQSPGNKMTACQNDNHLPAQVLPHTGTAKTIKASKTLRQKRSSSI |
| Organism_Source | Mus musculus |
| Functional_Classification | G protein-coupled receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | Gprc6a |
| UniProt_ID | Q8K4Z6 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Metabolitin |
|---|---|
| Peptide_Sequence | YLGASVPSPDPLEPT |
| Peptide_Length | 15 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)[C@@H](C)O)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1542.71 |
|---|---|
| Aliphatic_Index | 78.00000 |
| Aromaticity | 0.06667 |
| Average_Rotatable_Bonds | 2.66667 |
| Charge_at_pH_7 | -2.00064 |
| Isoelectric_Point | 3.55007 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 22 |
| Number_of_Hydrogen_Bond_Donors | 18 |
| Topological_Polar_Surface_Area | 591.08000 |
| X_logP_energy | -5.73700 |
Interaction Information
| Affinity | IC50=20 nM |
|---|---|
| Affinity_Assay | fluorescence-labeled ligand binding assay |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Newly identified peptide hormone inhibits intestinal fat absorption and improves NAFLD through its receptor GPRC6A |
| Release_Year | 2020 |
| PMID | 32147363 |
| DOI | 10.1016/j.jhep.2020.02.026 |