PPIRE15838

Target Protein Information
Protein_Name TGF-beta receptor type-2
Protein_Sequence MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
Organism_Source Homo sapiens
Functional_Classification serine threonine kinase receptors
Cellular_Localization Plasma membrane
Gene_Names TGFBR2
UniProt_ID P37173
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name IM-1
Peptide_Sequence ECGLLPVGRPDRNVWRWLC
Peptide_Length 19
Peptide_SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)O)C(C)C)C(C)C
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C1<-->C18; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2269.67
Aliphatic_Index 92.10526
Aromaticity 0.10526
Average_Rotatable_Bonds 3.57895
Charge_at_pH_7 0.87625
Isoelectric_Point 8.23142
Number_of_Hydrogen_Bond_Acceptors 28
Number_of_Hydrogen_Bond_Donors 34
Topological_Polar_Surface_Area 904.51000
X_logP_energy -5.83749
Interaction Information
Affinity KD=1 uM
Affinity_Assay ELISA
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title The effect of TGF-u receptor binding peptides on smooth muscle cells
Release_Year 2002
PMID None
DOI 10.1006/bbrc.2002.0378