PPIRE15840
Target Protein Information
| Protein_Name | None |
|---|---|
| Protein_Sequence | MKARFARRMEKIVEERMTVKQIFNRYVQTSTLHGFRFIFMDTFIVRRVLWTILTLTMATIFFKELRNSINLFYEYPFTTTSTIQYEPSLTFPAISVCNLNHFLLSKIKKSKLKPLYDQGRLPFDNNLENPGFDIQGEELYSILKTSSQSIDEIFLSCEWKSRDTAKNGVPNPCKPNNFTVYSGLYGQSCYTFNPGVSGYPLLSLSETGVNMGFKLELDLKSKDSLQGIQEIGAIVIVHHQQETPVLQAGFVVSPGFQTFVEIKVRQTENLPPPYATKCGSKPLKNYQIYRQSSCFLEQLGDAIETKCKCKSSFMAGRNIPYCSLRQTVTCLMPTIYDFDRKTNNNCPVDCETIQYLSSLSYARFISNVTYLSKNAEQSSYIRKLKNSMSPKKLQKYIEENIVAVQFFYQEMKKEKVKQEPSYDFYKLIGDVGGQLGLLLGASVLTLVEFVDLFIFTLYHQLLRLSKKKS/MLNFQDIAQITVEAIQEKNELPNEEEKNTQHPRDLRNKKIKEHISYMIDNSSFHGLSYIFDKRHSIRRTIWFFITIAAFVYAMQKVYESTMNYFSYPFYTARMRMYVNQINFPAVSFCNLNDIRFSVMNGTIVDDAIINNNQEANITGEEMRTFIQAARHTLKEMLVDCDFEGKKCSYENFTEFSWMQGESCFTFNSGKPPHTLLKVNGAGINRSLKLTINVQHYEYYRDKMDAGIHLILHGQDETPVKMRGLHLPPGFTSYIQIEKKTIINLEAPYKTKCGSVELKYFDSYSMHTCWLEQLTDHVYKVCKCKDVFMPGDIPICSFDEAFNCMWPQWETFDKLKLYHCPLPCKIDSYAVSLSRALFPTARYASSLANELRKHQHVAMNLKSNTDELAFMRENLLRLVIYYDDLSYELLEQKPNYDTLVWLGDVGGQIGLFIGAGVMSYFEFIDCLAMILYTRFFEKFTTK/MPQKKKLKEIAEERLNAKEIFSRYIEASTLHGYAYVCSDTFYIRRVLWAVLMLLGGIYFVFKLKVGIIEYFQYPFSTLSTEDFPEVLTFPAISICPINNFNISRVQNSILKQLYDADRLPLDKNWIDPGFDIPGNELADILKRSSLQIDKMHFYCDWISRNTTHPYIGPNPCGIENFTEYFNFKDQLCFTLNSGKKGFNLLSVDHEGLTYGYELGLDVHTNEIISSYPYNGIKLIIHNQQESPVMSDGFVISPGDRTFIKMATVEKKSLQPPYSTECGSVELKYHSVYNRRACLLELLTEYLGLKCGCRSLYMPDNGMQYCSLKETFTCMFPAQESFNEYEMGKRCPVECNSITFKHELTYSRYQPQSVSVPLMETLSTKNITRPVLKLMKEKNMGYNEIINYIRENIIFVIFFFGDMKKEVHEQEATFDFYQFLGDMGGEIGLMLGASLLTFVEFMDLLIFFVYHQLLRIQS |
| Organism_Source | Hydra vulgaris/Hydra vulgaris/Hydra vulgaris |
| Functional_Classification | peptide gated ion channels |
| Cellular_Localization | Plasma membrane |
| Gene_Names | hynac2/hynac3/hynac5 |
| UniProt_ID | A8DZR6/A8DZR7/D3UD58 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Hydra-RFamide II |
|---|---|
| Peptide_Sequence | QWFNGRF |
| Peptide_Length | 7 |
| Peptide_SMILES | N=C(N)NCCC[C@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | pyroglutamate |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 954.06 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.42857 |
| Average_Rotatable_Bonds | 4.00000 |
| Charge_at_pH_7 | 0.99798 |
| Isoelectric_Point | 10.55000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 11 |
| Number_of_Hydrogen_Bond_Donors | 14 |
| Topological_Polar_Surface_Area | 401.79000 |
| X_logP_energy | -2.44793 |
Interaction Information
| Affinity | EC50=0.14 uM |
|---|---|
| Affinity_Assay | Patch-clamp electrophysiology |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Efficient expression of a cnidarian peptide-gated ion channel in mammalian cells |
| Release_Year | 2021 |
| PMID | 33522420 |
| DOI | 10.1080/19336950.2021.1882762 |