PPIRE15841
Target Protein Information
| Protein_Name | C-terminal-binding protein 1 |
|---|---|
| Protein_Sequence | MGSSHLLNKGLPLGVRPPIMNGPLHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRATWLHQALREGTRVQSVEQIREVASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGVERALGLQRVSTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPDSLKNCVNKDHLTAATHWASMDPAVVHPELNGAAYRYPPGVVGVAPTGIPAAVEGIVPSAMSLSHGLPPVAHPPHAPSPGQTVKPEADRDHASDQL |
| Organism_Source | Homo sapiens |
| Functional_Classification | transcriptional co repressors |
| Cellular_Localization | Nucleus |
| Gene_Names | CTBP1 |
| UniProt_ID | Q13363 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | TAT-E1A-WT |
|---|---|
| Peptide_Sequence | YGRKKRRQRRREPGQPLDLSCQRPRDYKDDDDK |
| Peptide_Length | 33 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | none |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 4132.59 |
|---|---|
| Aliphatic_Index | 23.63636 |
| Aromaticity | 0.06061 |
| Average_Rotatable_Bonds | 4.36364 |
| Charge_at_pH_7 | 4.93756 |
| Isoelectric_Point | 10.55466 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 60 |
| Number_of_Hydrogen_Bond_Donors | 73 |
| Topological_Polar_Surface_Area | 2018.49000 |
| X_logP_energy | -24.26414 |
Interaction Information
| Affinity | IC50=5.6 uM |
|---|---|
| Affinity_Assay | AlphaScreen |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | CPP-E1A Fusion Peptides Inhibit CtBP-Mediated Transcriptional Repression |
| Release_Year | 2018 |
| PMID | 29879296 |
| DOI | 10.1002/1878-0261.12330 |