PPIRE15844

Target Protein Information
Protein_Name Apical membrane antigen 1
Protein_Sequence CPVFGKGIIIENSKTTFLTPVATENQDLKDGGFAFPPTKPLMSPMTLDHMRDFYKDNEYVKNLDELTLCSRHAGNMNPDNDKNSNYKYPAVYDYNDKKCHILYIAAQENNGPRYCNKDESKRNSMFCFRPAKDISFQNYTYLSKNVVDNWEKVCPRKNLQNAKFGLWVDGNCEDIPHVNEFSANDLFECNKLVFELSASDQPKQYEQHLTDYEKIKEGFKNKNASMIKSAFLPTGAFKADRYKSHGKGYNWGNYNTETHKCEIFNVKPTCLINNSSYIATTALSHPIEVENNFPCSLYKDEIMKEIERESKRIKLNDNDDEGNKKIIAPRIFISDDKDSLKCPCDPEMVSNSTCRFFVCKCVERRAEVTSNNEVVVKEEYKDEYADIPEHKPTYDNMKIIIASSAAVAVLATILMVYLYKRKGNAEKYDKMDEPQHYGKSNSRNDEMLD
Organism_Source Plasmodium falciparum
Functional_Classification type I integral membrane protein
Cellular_Localization Plasma membrane
Gene_Names AMA1
UniProt_ID A0A0X8IHV3
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name tF1
Peptide_Sequence GWTPLGFGPN
Peptide_Length 10
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1045.16
Aliphatic_Index 39.00000
Aromaticity 0.20000
Average_Rotatable_Bonds 2.60000
Charge_at_pH_7 -0.00202
Isoelectric_Point 6.10000
Number_of_Hydrogen_Bond_Acceptors 13
Number_of_Hydrogen_Bond_Donors 12
Topological_Polar_Surface_Area 386.75000
X_logP_energy -3.06290
Interaction Information
Affinity IC50=10 uM
Affinity_Assay merozoite invasion assay
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Research Articles
Title Structures of Phage-Display Peptides that Bind to the Malarial Surface Protein Apical Membrane Antigen 1 and Block Erythrocyte Invasion
Release_Year 2003
PMID 12924940
DOI 10.1021/bi034376b