PPIRE15849
Target Protein Information
| Protein_Name | Bifunctional coenzyme PQQ synthesis protein C/D |
|---|---|
| Protein_Sequence | MTAQFPPPVPDTEQRLLSHEELEAALRDIGARRYHNLHPFHRLLHDGKLSKDQVRAWALNRYYYQAMIPVKDAALLARLPDAQLRRIWRQRIVDHDGDHEGDGGIERWLKLAEGVGFTRDYVLSTKGILSATRFSVDAYVHFVSERSLLEAIASSLTEMFSPTIISERVAGMLKNYDFITKDTLAYFDKRLTQAPRDADFALDYVKRHATTPEMQRAAIDALTFKCNVLWTQLDALYFAYVAPGMVPPDAWQPGEGLVAETNSAEDSPAAAASPAATTAEPTAFSGSDVPRLPRGVRLRFDEVRNKHVLLAPERTFDLDDNAVAVLKLVDGRNTVSQIAQILGQTYDADPAIIEADILPMLAGLAQKRVLER |
| Organism_Source | Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) |
| Functional_Classification | radical S adenosylmethionine enzymes |
| Cellular_Localization | Cytoplasm |
| Gene_Names | pqqCD |
| UniProt_ID | Q49150 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | MePqqA |
|---|---|
| Peptide_Sequence | KWAAPIVSEISVGMEVTYSESAEIDTFN |
| Peptide_Length | 28 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)[C@@H](C)CC)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)C(C)C)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 3074.41 |
|---|---|
| Aliphatic_Index | 83.57143 |
| Aromaticity | 0.10714 |
| Average_Rotatable_Bonds | 3.50000 |
| Charge_at_pH_7 | -3.99561 |
| Isoelectric_Point | 3.67191 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 44 |
| Number_of_Hydrogen_Bond_Donors | 43 |
| Topological_Polar_Surface_Area | 1253.24000 |
| X_logP_energy | -11.87130 |
Interaction Information
| Affinity | KD=200 nM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | None |
| Type | Substrate |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | PqqD is a novel peptide chaperone that forms a ternary complex with the radical S- adenosylmethionine protein PqqE in the pyrroloquinoline quinone biosynthetic pathway |
| Release_Year | 2015 |
| PMID | 25817994 |
| DOI | 10.1074/jbc.M115.646521 |