PPIRE15886
Target Protein Information
| Protein_Name | None |
|---|---|
| Protein_Sequence | MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTVEGTSTGYTTPTAPQAYSQPVQGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYPMQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNPSYDSVRRGAWGNNMNSGLNKSPPLGGAQTISKNTEQRPQPDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSANASCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPTESSMYKYPSDISYMPSYHAHQQKVNFVPPHPSSMPVTSSSFFGAASQYWTSPTGGIYPNPNVPRHPNTHVPSHLGSYY |
| Organism_Source | Homo sapiens |
| Functional_Classification | Ets family transcription factor |
| Cellular_Localization | Nucleus |
| Gene_Names | EWSR1/FLI1 fusion |
| UniProt_ID | F1JVV7 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | ESAP1K |
|---|---|
| Peptide_Sequence | GKKKRT |
| Peptide_Length | 6 |
| Peptide_SMILES | C[C@@H](O)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CN)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | antennapedia |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 716.88 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 4.66667 |
| Charge_at_pH_7 | 3.99710 |
| Isoelectric_Point | 11.92451 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 12 |
| Number_of_Hydrogen_Bond_Donors | 14 |
| Topological_Polar_Surface_Area | 369.01000 |
| X_logP_energy | -4.51523 |
Interaction Information
| Affinity | KD=0.388 uM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | None |
| Type | Antagonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Novel peptide binds EWS-FLI1 and reduces the oncogenic potential in Ewing tumors |
| Release_Year | 2011 |
| PMID | 21926473 |
| DOI | 10.4161/cc.10.19.17734 |