PPIRE16082

Target Protein Information
Protein_Name Ribonuclease pancreatic
Protein_Sequence MALKSLVLLSLLVLVLLLVRVQPSLGKETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV
Organism_Source Bos taurus
Functional_Classification endoribonucleases
Cellular_Localization Extracellular
Gene_Names RNASE1
UniProt_ID P61823
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name S-peptide
Peptide_Sequence KETAAAKFERQHMDSSTSAA
Peptide_Length 20
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2166.35
Aliphatic_Index 25.00000
Aromaticity 0.05000
Average_Rotatable_Bonds 3.70000
Charge_at_pH_7 0.09230
Isoelectric_Point 7.54974
Number_of_Hydrogen_Bond_Acceptors 35
Number_of_Hydrogen_Bond_Donors 36
Topological_Polar_Surface_Area 1014.98000
X_logP_energy -14.59983
Interaction Information
Affinity KD=57 nM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Formation and properties of S-protein complex with S-peptide-containing fusion protein
Release_Year 1994
PMID None
DOI 10.1016/0014-5793(94)00030-Y