PPIRE16105
Target Protein Information
| Protein_Name | None |
|---|---|
| Protein_Sequence | GRKKRRQRRRAPPDSEVHQVSLPKQPASQLQGDSTGPKESKKKVERETETDPGH |
| Organism_Source | Simian-Human immunodeficiency virus 1 |
| Functional_Classification | viral transcription activators |
| Cellular_Localization | Nucleus |
| Gene_Names | tat |
| UniProt_ID | A0A0B4RUR0 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Tat-NLS |
|---|---|
| Peptide_Sequence | GRKKRRQRRRAHQN |
| Peptide_Length | 14 |
| Peptide_SMILES | C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1847.13 |
|---|---|
| Aliphatic_Index | 7.14286 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 4.92857 |
| Charge_at_pH_7 | 8.08828 |
| Isoelectric_Point | 13.20310 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 27 |
| Number_of_Hydrogen_Bond_Donors | 39 |
| Topological_Polar_Surface_Area | 1023.01000 |
| X_logP_energy | -14.43818 |
Interaction Information
| Affinity | KD=1 nM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Positively charged peptides can interact with each other as revealed by solid phase binding assays |
| Release_Year | 2006 |
| PMID | 16581010 |
| DOI | 10.1016/j.ab.2006.03.002 |