PPIRE16106
Target Protein Information
| Protein_Name | Protein Rev |
|---|---|
| Protein_Sequence | AGRSGDSDEELLQTVRFIKFLYQSSNPLPSSKGTRQARRNRRRRWRERQRQIQAISAWIISTHLGRSAEPVPLQLPPLERLNLDCSEDRGTSGTQGVGSPQVLGESPAVLDSGTKE |
| Organism_Source | Simian-Human immunodeficiency virus 1 |
| Functional_Classification | Viral regulatory proteins RNA binding regulators |
| Cellular_Localization | Nucleus |
| Gene_Names | rev |
| UniProt_ID | A0A0B4Q633 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Rev-NLS |
|---|---|
| Peptide_Sequence | RQARRNRRRRWR |
| Peptide_Length | 12 |
| Peptide_SMILES | C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1767.04 |
|---|---|
| Aliphatic_Index | 8.33333 |
| Aromaticity | 0.08333 |
| Average_Rotatable_Bonds | 5.16667 |
| Charge_at_pH_7 | 7.99796 |
| Isoelectric_Point | 13.34511 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 23 |
| Number_of_Hydrogen_Bond_Donors | 40 |
| Topological_Polar_Surface_Area | 980.59000 |
| X_logP_energy | -12.27794 |
Interaction Information
| Affinity | KD=1 nM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Positively charged peptides can interact with each other as revealed by solid phase binding assays |
| Release_Year | 2006 |
| PMID | 16581010 |
| DOI | 10.1016/j.ab.2006.03.002 |