PPIRE16155

Target Protein Information
Protein_Name Polyubiquitin-B
Protein_Sequence MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGC
Organism_Source Homo sapiens
Functional_Classification ubiquitin
Cellular_Localization Cytoplasm
Gene_Names UBB
UniProt_ID P0CG47
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name DPDELRFNAIAL-NH2
Peptide_Sequence DPDELRFNAIAL
Peptide_Length 12
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1373.53
Aliphatic_Index 114.16667
Aromaticity 0.08333
Average_Rotatable_Bonds 3.58333
Charge_at_pH_7 -1.99935
Isoelectric_Point 3.87601
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 19
Topological_Polar_Surface_Area 591.52000
X_logP_energy -4.38903
Interaction Information
Affinity KD=10 mM
Affinity_Assay Isothermal Titration Calorimetry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Ubiquitin Binds to a Short Peptide Segment of Hydrolase UCH-L3: A Study by FCS RIfS ITC and NMR
Release_Year 2007
PMID 17211910
DOI 10.1002/cbic.200600254