PPIRE16163
Target Protein Information
| Protein_Name | Disintegrin and metalloproteinase domain-containing protein 10 |
|---|---|
| Protein_Sequence | MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR |
| Organism_Source | Homo sapiens |
| Functional_Classification | metalloproteases |
| Cellular_Localization | Plasma membrane |
| Gene_Names | ADAM10 |
| UniProt_ID | O14672 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | H-KTEEISEVNX VAEF |
|---|---|
| Peptide_Sequence | KTEEISEVNXVAEF |
| Peptide_Length | 14 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C |
| Chemical_Modification | X11=statine |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | acid |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1551.67 |
|---|---|
| Aliphatic_Index | 76.42857 |
| Aromaticity | 0.07143 |
| Average_Rotatable_Bonds | 3.78571 |
| Charge_at_pH_7 | -2.99521 |
| Isoelectric_Point | 3.81972 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 23 |
| Number_of_Hydrogen_Bond_Donors | 23 |
| Topological_Polar_Surface_Area | 700.39000 |
| X_logP_energy | -7.21050 |
Interaction Information
| Affinity | IC50=30 nM |
|---|---|
| Affinity_Assay | Enzyme Inhibition Kinetics |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Amyloid peptides mediate hypoxic increase of L-type Ca2+ channels in central neurones |
| Release_Year | 2006 |
| PMID | 16464656 |
| DOI | 10.1016/j.neurobiolaging.2005.02.002 |