PPIRE16178

Target Protein Information
Protein_Name 14-3-3 protein zeta/delta
Protein_Sequence MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN
Organism_Source Homo sapiens
Functional_Classification 14-3-3 proteins
Cellular_Localization Cytoplasm
Gene_Names YWHAZ
UniProt_ID P63104
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name IuBupS63
Peptide_Sequence AAAAAAPRGSEPW
Peptide_Length 13
Peptide_SMILES C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O
Chemical_Modification S10=phosphoserine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification FITC
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1254.37
Aliphatic_Index 46.15385
Aromaticity 0.07692
Average_Rotatable_Bonds 2.53846
Charge_at_pH_7 -0.00024
Isoelectric_Point 6.41015
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 530.16000
X_logP_energy -6.17653
Interaction Information
Affinity KD=380 uM
Affinity_Assay Fluorescence Polarization
PDB_ID 6Y1J
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Interaction of an IuBu Peptide with 14-3-3
Release_Year 2020
PMID 32201828
DOI 10.1021/acsomega.9b04413