PPIRE16186
Target Protein Information
| Protein_Name | RNA-binding protein RO60 |
|---|---|
| Protein_Sequence | MEESVNQMQPLNEKQIANSQDGYVWQVTDMNRLHRFLCFGSEGGTYYIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTTKQEPMLFALAICSQCSDISTKQAAFKAVSEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAIADWYNEKGGMALALAVTKYKQRNGWSHKDLLRLSHLKPSSEGLAIVTKYITKGWKEVHELYKEKALSVETEKLLKYLEAVEKVKRTRDELEVIHLIEEHRLVREHLLTNHLKSKEVWKALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLVCEKLCNEKLLKKARIHPFHILIALETYKTGHGLRGKLKWRPDEEILKALDAAFYKTFKTVEPTGKRFLLAVDVSASMNQRVLGSILNASTVAAAMCMVVTRTEKDSYVVAFSDEMVPCPVTTDMTLQQVLMAMSQIPAGGTDCSLPMIWAQKTNTPADVFIVFTDNETFAGGVHPAIALREYRKKMDIPAKLIVCGMTSNGFTIADPDDRGMLDMCGFDTGALDVIRNFTLDMI |
| Organism_Source | Homo sapiens |
| Functional_Classification | ribonucleoproteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | RO60 |
| UniProt_ID | P10155 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Ro-MAP-166 |
|---|---|
| Peptide_Sequence | LAVTKYKQRNGWSHK |
| Peptide_Length | 15 |
| Peptide_SMILES | CC(C)C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1816.10 |
|---|---|
| Aliphatic_Index | 52.00000 |
| Aromaticity | 0.13333 |
| Average_Rotatable_Bonds | 4.06667 |
| Charge_at_pH_7 | 4.08715 |
| Isoelectric_Point | 11.13194 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 26 |
| Number_of_Hydrogen_Bond_Donors | 29 |
| Topological_Polar_Surface_Area | 802.02000 |
| X_logP_energy | -7.65873 |
Interaction Information
| Affinity | KD=2.09 mM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Anti-Ro fine specificity defined by multiple antigenic peptides identifies components of tertiary epitopes |
| Release_Year | 1997 |
| PMID | None |
| DOI | 10.1046/j.1365-2249.1997.3130506.x |