PPIRE16245

Target Protein Information
Protein_Name Potassium channel subfamily K member 2
Protein_Sequence MLASASRERPGYTAGVAAPDLLDPKSAAQNSKPRLSFSSKPTVLASRVESDSAINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPQEISQRTTIVIQKQTFIAQHACVNSTELDELIQQIVAAINAGIIPLGNSSNQVSHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAVIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATSVKRKLSAELAGNHNQELTPCRRTLSVNHLTSEREVLPPLLKAESIYLNGLTPHCAGEDIAVIENMK
Organism_Source Mus musculus
Functional_Classification two pore domain potassium channels
Cellular_Localization Plasma membrane
Gene_Names Kcnk2
UniProt_ID P97438
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name spadin
Peptide_Sequence YAPLPRWSGPIGVSWGLR
Peptide_Length 18
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2012.34
Aliphatic_Index 86.66667
Aromaticity 0.16667
Average_Rotatable_Bonds 3.05556
Charge_at_pH_7 1.99713
Isoelectric_Point 11.14762
Number_of_Hydrogen_Bond_Acceptors 24
Number_of_Hydrogen_Bond_Donors 27
Topological_Polar_Surface_Area 747.72000
X_logP_energy -4.22566
Interaction Information
Affinity KD=10 nM
Affinity_Assay Radioligand binding assay
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Research Articles
Title Spadin a Sortilin-Derived Peptide Targeting Rodent TREK-1 Channels: A New Concept in the Antidepressant Drug Design
Release_Year 2010
PMID 20405001
DOI 10.1371/journal.pbio.1000355