PPIRE16271

Target Protein Information
Protein_Name Mitogen-activated protein kinase 8
Protein_Sequence MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAAGPLGCCR
Organism_Source Homo sapiens
Functional_Classification protein serine threonine kinases
Cellular_Localization Cytoplasm
Gene_Names MAPK8
UniProt_ID P45983
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SID7
Peptide_Sequence MHFKTASDCP
Peptide_Length 10
Peptide_SMILES CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification fluorescein rhodamine
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1136.31
Aliphatic_Index 10.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 3.40000
Charge_at_pH_7 0.02707
Isoelectric_Point 7.35900
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 448.89000
X_logP_energy -4.84420
Interaction Information
Affinity KD=36.2 mM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Selective targeting of MAPK family kinases JNK over p38 by rationally designed peptides as potential therapeutics for neurological disorders and epilepsy
Release_Year 2016
PMID 27263470
DOI 10.1039/c6mb00297h