PPIRE16292

Target Protein Information
Protein_Name Transforming growth factor beta-1 proprotein
Protein_Sequence MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
Organism_Source Homo sapiens
Functional_Classification growth factors
Cellular_Localization Extracellular
Gene_Names TGFB1
UniProt_ID P01137
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name KRIWFIPRSSWY
Peptide_Sequence KRIWFIPRSSWY
Peptide_Length 12
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1638.94
Aliphatic_Index 65.00000
Aromaticity 0.33333
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 2.99683
Isoelectric_Point 11.53052
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 616.72000
X_logP_energy -1.39136
Interaction Information
Affinity KD=10.41 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Affinity Peptides Protect Transforming Growth Factor Beta During Encapsulation in Poly(ethylene glycol) Hydrogels
Release_Year 2011
PMID 21375234
DOI 10.1021/bm101379v