PPIRE16301

Target Protein Information
Protein_Name None
Protein_Sequence MDISLSLVFLVLFIKGVQCEVQLVETGGGLVQPGRSLKLSCVASGFTFSSYWMYWIRQAPGKGLEWVSSINTDGGSTYYPDSVKGRFTISRDNAENTVYLQMNSLRSEDTATYYCAKGGEYYGYNYPFDYWGQGVMVTVSSAETTAPSVYPLAPGTALKSNSMVTLGCLVKGYFPEPVTVTWNSGALSSGVHTFPAVLQSGLYTLTSSVTVPSSTWPSQTVTCNVAHPASSTKVDKKIVPRNCGGDCKPCICTGSEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISQDDPEVHFSWFVDDVEVHTAQTRPPEEQFNSTFRSVSELPILHQDWLNGRTFRCKVTSAAFPSPIEKTISKPEGRTQVPHVYTMSPTKEEMTQNEVSITCMVKGFYPPDIYVEWQMNGQPQENYKNTPPTMDTDGSYFLYSKLNVKKEKWQQGNTFTCSVLHEGLHNHHTEKSLSHSPGK
Organism_Source Rattus norvegicus
Functional_Classification immunoglobulin
Cellular_Localization Extracellular
Gene_Names Ighg
UniProt_ID Q4VBH1
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name MBP14770
Peptide_Sequence QGTLSKIFKLGGRDSRSGSPMARR
Peptide_Length 24
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification biotinylation
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2606.00
Aliphatic_Index 52.91667
Aromaticity 0.04167
Average_Rotatable_Bonds 3.79167
Charge_at_pH_7 4.99783
Isoelectric_Point 12.51643
Number_of_Hydrogen_Bond_Acceptors 39
Number_of_Hydrogen_Bond_Donors 45
Topological_Polar_Surface_Area 1205.01000
X_logP_energy -16.86422
Interaction Information
Affinity KD=8 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Liposome-encapsulated peptides protect against experimental allergic encephalitis
Release_Year 2013
PMID 23047895
DOI 10.1096/fj.12-213975