PPIRE16346

Target Protein Information
Protein_Name Protein Tat
Protein_Sequence MEPVDPRLEPWNHPGSQPKTACNNCYCKRCCYHCLYCFTKKGLGISYGRKKRSQRRRTPQSSKSHQDLIPEQPLSQQQGDQTGQKKQKEALESKTEADPCD
Organism_Source Human immunodeficiency virus type 1 group N (isolate YBF30)
Functional_Classification Viral transcriptional activators
Cellular_Localization Nucleus
Gene_Names tat
UniProt_ID O91083
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name p53(32655)
Peptide_Sequence EYFTLQIRGRERFEMFRELNEALELKDAQA
Peptide_Length 30
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3704.17
Aliphatic_Index 75.00000
Aromaticity 0.13333
Average_Rotatable_Bonds 4.30000
Charge_at_pH_7 -1.99208
Isoelectric_Point 4.50617
Number_of_Hydrogen_Bond_Acceptors 49
Number_of_Hydrogen_Bond_Donors 56
Topological_Polar_Surface_Area 1611.67000
X_logP_energy -12.55862
Interaction Information
Affinity KD=31 uM
Affinity_Assay fluorescence anisotropy
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Using Peptides to Study the Interaction between the p53 Tetramerization Domain and HIV-1 Tat
Release_Year 2008
PMID 18189286
DOI 10.1002/bip.20919