PPIRE16355

Target Protein Information
Protein_Name Beta sliding clamp
Protein_Sequence MKFTVEREHLLKPLQQVSGPLGGRPTLPILGNLLLQVADGTLSLTGTDLEMEMVARVALVQPHEPGATTVPARKFFDICRGLPEGAEIAVQLEGERMLVRSGRSRFSLSTLPAADFPNLDDWQSEVEFTLPQATMKRLIEATQFSMAHQDVRYYLNGMLFETEGEELRTVATDGHRLAVCSMPIGQSLPSHSVIVPRKGVIELMRMLDGGDNPLRVQIGSNNIRAHVGDFIFTSKLVDGRFPDYRRVLPKNPDKHLEAGCDLLKQAFARAAILSNEKFRGVRLYVSENQLKITANNPEQEEAEEILDVTYSGAEMEIGFNVSYVLDVLNALKCENVRMMLTDSVSSVQIEDAASQSAAYVVMPMRL
Organism_Source Escherichia coli (strain K12)
Functional_Classification sliding clamp
Cellular_Localization Cytoplasm
Gene_Names dnaN
UniProt_ID P0A988
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name pepMucB-n
Peptide_Sequence EAQLDLFDS
Peptide_Length 9
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1037.09
Aliphatic_Index 97.77778
Aromaticity 0.11111
Average_Rotatable_Bonds 3.77778
Charge_at_pH_7 -2.99935
Isoelectric_Point 3.38003
Number_of_Hydrogen_Bond_Acceptors 15
Number_of_Hydrogen_Bond_Donors 15
Topological_Polar_Surface_Area 471.34000
X_logP_energy -4.29650
Interaction Information
Affinity KD=0.51 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Inhibition of Protein Interactions with the u2 Sliding Clamp of Escherichia coli DNA Polymerase III by Peptides from u2-Binding Proteins
Release_Year 2004
PMID 15134440
DOI 10.1021/bi036229j