PPIRE16357

Target Protein Information
Protein_Name Beta sliding clamp
Protein_Sequence MKFTVEREHLLKPLQQVSGPLGGRPTLPILGNLLLQVADGTLSLTGTDLEMEMVARVALVQPHEPGATTVPARKFFDICRGLPEGAEIAVQLEGERMLVRSGRSRFSLSTLPAADFPNLDDWQSEVEFTLPQATMKRLIEATQFSMAHQDVRYYLNGMLFETEGEELRTVATDGHRLAVCSMPIGQSLPSHSVIVPRKGVIELMRMLDGGDNPLRVQIGSNNIRAHVGDFIFTSKLVDGRFPDYRRVLPKNPDKHLEAGCDLLKQAFARAAILSNEKFRGVRLYVSENQLKITANNPEQEEAEEILDVTYSGAEMEIGFNVSYVLDVLNALKCENVRMMLTDSVSSVQIEDAASQSAAYVVMPMRL
Organism_Source Escherichia coli (strain K12)
Functional_Classification sliding clamp
Cellular_Localization Cytoplasm
Gene_Names dnaN
UniProt_ID P0A988
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name pepHda-e
Peptide_Sequence IGQLSLPLGV
Peptide_Length 10
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@H](C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 996.21
Aliphatic_Index 185.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.10000
Charge_at_pH_7 -0.00202
Isoelectric_Point 6.10000
Number_of_Hydrogen_Bond_Acceptors 13
Number_of_Hydrogen_Bond_Donors 12
Topological_Polar_Surface_Area 379.75000
X_logP_energy -2.37130
Interaction Information
Affinity KD=0.45 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Inhibition of Protein Interactions with the u2 Sliding Clamp of Escherichia coli DNA Polymerase III by Peptides from u2-Binding Proteins
Release_Year 2004
PMID 15134440
DOI 10.1021/bi036229j