PPIRE16358

Target Protein Information
Protein_Name Beta sliding clamp
Protein_Sequence MKFTVEREHLLKPLQQVSGPLGGRPTLPILGNLLLQVADGTLSLTGTDLEMEMVARVALVQPHEPGATTVPARKFFDICRGLPEGAEIAVQLEGERMLVRSGRSRFSLSTLPAADFPNLDDWQSEVEFTLPQATMKRLIEATQFSMAHQDVRYYLNGMLFETEGEELRTVATDGHRLAVCSMPIGQSLPSHSVIVPRKGVIELMRMLDGGDNPLRVQIGSNNIRAHVGDFIFTSKLVDGRFPDYRRVLPKNPDKHLEAGCDLLKQAFARAAILSNEKFRGVRLYVSENQLKITANNPEQEEAEEILDVTYSGAEMEIGFNVSYVLDVLNALKCENVRMMLTDSVSSVQIEDAASQSAAYVVMPMRL
Organism_Source Escherichia coli (strain K12)
Functional_Classification sliding clamp
Cellular_Localization Cytoplasm
Gene_Names dnaN
UniProt_ID P0A988
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name pepHda-n
Peptide_Sequence PAQLSLPLYL
Peptide_Length 10
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1114.35
Aliphatic_Index 166.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 3.20000
Charge_at_pH_7 -0.00287
Isoelectric_Point 6.09320
Number_of_Hydrogen_Bond_Acceptors 14
Number_of_Hydrogen_Bond_Donors 13
Topological_Polar_Surface_Area 385.99000
X_logP_energy -0.89720
Interaction Information
Affinity KD=0.38 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Inhibition of Protein Interactions with the u2 Sliding Clamp of Escherichia coli DNA Polymerase III by Peptides from u2-Binding Proteins
Release_Year 2004
PMID 15134440
DOI 10.1021/bi036229j