PPIRE16371

Target Protein Information
Protein_Name Transcriptional enhancer factor TEF-1
Protein_Sequence MEPSSWSGSESPAENMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSRDFHSKLKDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGAPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVTSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD
Organism_Source Homo sapiens
Functional_Classification TEA domain transcription factors
Cellular_Localization Nucleus
Gene_Names TEAD1
UniProt_ID P28347
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name cyclo-YAP84-100-Nle91
Peptide_Sequence VPMCLRKXPASFCKPPE
Peptide_Length 17
Peptide_SMILES CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method side chain-side chain cyclization; Cys87<-->Cys96; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Acetyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1860.28
Aliphatic_Index 45.88235
Aromaticity 0.05882
Average_Rotatable_Bonds 3.23529
Charge_at_pH_7 1.87522
Isoelectric_Point 8.82156
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 665.23000
X_logP_energy -5.23293
Interaction Information
Affinity KD=0.6 mM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Targeting Hippo pathway by specific interruption of YAP-TEAD interaction using cyclic YAP-like peptides
Release_Year 2015
PMID 25384421
DOI 10.1096/fj.14-262980